Quinolone(Nalidixic acid) uses, adverse effects

Quinolones

These are synthetic antimicrobials having a quinolone structure and are active against gram negative bacteria.

Nalidixic acid is the first member.

Nalidixic acid

1.It is active against gram- negative bacteria especially E. Coli, proteus, klebsiella.

Adverse effects of Nalidixic acid

1. Individuals with G-6PD deficiency may develop haemolysis.

2. Phototoxicty is rare.

3. Consist mainly of g. i upset and rashes.

4. Most important toxicity is neurological- headche, drowsiness, vertigo, visual disturbance, seizures.

Uses of nalidixic acid-

1. used as urinary antiseptic.

2. Used in diarrhoea caused by shigella, E. Coli and proteus.

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