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Uses of chloramphenicol

          USES OF CHLORAMPHENICOL



1) H. Influenza Meningitis-

Chloramphenicol is highly efficacious and it has excellent penetrability into CSF. 

2) Intraocular Infections-

Chloramphenicol given systemically attains high  concentration in ocular fluids. It is the preffered drug for endophthalmitis caused by sensitive organism. 

3) Topically-

In conjunctivitis, external ear infection chloramphenicol 0.5-5.0%is highly effective. 



4) Enteric Fever-


Till recently chloramphenicol was the drug of choice for typhoid fever. Chloramphenicol does not prevent or cure carrier state. 


5) Anaerobic Infections-

It is effective in anaerobic infections caused by Bact. fragilis and other wound infections and brain abscesses. 

6) As second choice drug-drug-

a)  To Erythromycin - for whooping cough. 

b) To tetracycline- for brucellosis and rickettsial infections especially in children and pregnant women in whom tetracycline are contraindicated. 

c) To penicillin- for meningococcal or pneumococcal meningitis. 

d) To cotrimoxazole-for shigella dysentry enteritis. 
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