Broad spectrum antibiotics

BROAD SPECTRUM ANTIBIOTICS

Tetracyclines and chloramphenicol

Tetracyclines

These are class of antibiotics having a nucleus of four cyclic rings.

Chemical structure:

The tetracyclines still available in India for clinical use are-

Tetracycline Democlocycline

Oxytetracycline Doxycycline

Minocycline

Chloramphenicol

In 1947 chloramphenicol was obtained from streptomyces Venezuelae.

Chemical structure

The chloramphenicol has a nitrobenezene substitution which is responsible for antibacterial activity and it's bitter taste.

Most commonly used broad-spectrum antibiotic is ampicillin.

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